Rabbi Meir allows a man to verbally designate tithes and leave them in the bottle (ideally they should be physically separated, here he has no other containers). Then he can drink the wine, and leave over the tithes at the bottom of the bottle.
The other sages challenge rabbi Meir, arguing that not only must the tithes be physically separate, but if the bottle breaks then the tithes never get separated and the man was drinking unfixed wine, a serious transgression. Rabbi Meir answers When it will break we can worry about it.
This is a fundamental argument in how to live your life. Some people worry about every thing that could go badly. They can develop anxiety about starting new activities and approaching novel situations.
Rabbi Meir advises a man to go ahead with life, and when something goes wrong deal with it then. Obviously he isn’t flippant about danger, the bible tells us not to out ourselves into danger. Rabbi Meir teaches us to live with the inherent risks of taking action without suffering anxiety. Go ahead and approach, knowing there is a risk, and keep going anyway.